For many children, PANS and PANDAS do not simply resolve without treatment, particularly when the underlying infection and immune process are not addressed. Episodes can persist and cycle. The clinical literature suggests that earlier treatment is associated with better outcomes than delayed treatment — not because children who were not treated quickly cannot improve, but because prompt treatment gives the best possible foundation for recovery. When episodes go unrecognized or untreated, neuropsychiatric symptoms can become more entrenched over time, and children may receive treatments that address symptoms without addressing the underlying biological process. Many families face barriers to getting appropriate care through no fault of their own. If you are in that situation, continuing to advocate for evaluation is worth it.